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Microporus Surface

Microporus Surface

YUKON Choice PC has microporous surface that enables drug loading and also participates in the process of slow drug release .The bonding of the drug layer is firm due to the Van-der-Waals forces between the drug and the surface. Microporous surface enables the use of very small amount of biodegradable polymer for achieving the optimum drug loading and drug release.

The idea of microporous surface

Electropolished coronary stents represent the standard surface in PTCA for more than a decade. Manufacturing companies tried to improve the sophisticated electro-polishing processes to obtain ideal smooth stent surface, proven by optically nice Scanning Electron Microscopy pictures. But the question is - are these smooth surfaces really biologically necessary? Are they an important element for clinical success?

Basic research articles and also products in other biomedical fields like orthopaedic implants are showing that human cells in general prefer structured surfaces, not only for better binding or attachment of the cell, but also for faster growth. Close cell-cell contacts additionally enhance this essential proliferative process.

Translumina Therapeutics’s surface technology is based on known procedures from aerospace industries with non chemical processes. The resulting surface appearance is microscopically rough and contains micro pores with a density of 1 million pores per cm². The average depth of the micro pores is approx. 2 micrometers. One technical advantage of this technology is the increased mechanical strength due to the compressed material on the stent surface. Depending on the stent material composition - additional increase in radial force, as well as in fatigue properties - can be achieved. This process can be used for different metal alloys, the process parameters can be adjusted in order to get bigger or smaller micro pores and also to change their shape. This technology is used since many years successfully for the surface treatment of bone implants, which proves the principal biocompatibility in the long term.

Pictures:The topography of the stent shows a homogenous microstructure as a result of the surface compressing process. The biocompatibility testing showed positive effects from the micro structured surface to the vessel wall and the biological system in general.