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Abluminal Coating

Abluminal Coating

YUKON choice PC has better arterial healing due to lesser biodegradable polymeric load that degrades in 6-9 months leaving behind a BMS. In addition, drug and polymer are only present on the abluminal side of the Stent.

Morphology of a healthy vessel:

A healthy vessel is composed of 3 layers of different kind of cells:

  • The adventitia. This is the outermost layer, mainly composed of collagen. This gives the stability of the vessel
  • The media, is composed of smooth muscle cells. These cells are responsible for the contractile properties of the artery, to allow the blood to lead toward the organs the vessel is feeding.
  • The intima, is the innermost layer. It is a one cell thick layer of endothelial cells, also called the endothelium.

At stent implantation, the tissue of the vessel wall is damaged. The endothelium will be destroyed, the smooth muscle cells will be compressed up to the adventitia. The adventitia itself won’t be dramatically affected.

After stent implantation we have the struts of the stent in contact with the blood stream. The healing is the growth of endothelial cells coming from the healthy neighboring tissue which will cover the struts of the stent. This process is in place after 30 days where we can already observe a healthy layer of cells covering the struts. The healing is a critical process as it will prevent a possible late event after stent implantation. We have also to keep in mind that the strut thickness is not a limitation to the healing process as long as the stent is well apposed (embedded into the tissue).

Factors Impacting Re-endothelialization

The type of coating, the type and the thickness of drug carrier, as well as the type of drug will affect the healing process.

The Abluminal coating reduces the systemic exposure and the risk of delayed healing.

An abluminal coating means that you don’t have any drug carrier or drug on the inside of the stent, so YUKON Choice PC reduces the systemic exposure, which avoids a delay in healing.

Reduced Inflammation due to lower Polymeric Load

When the polymer thickness is reduced, the inflammatory reaction is reduced because we know that the inflammation is proportional to the thickness of drug carrier.

Most of the DES use durable drug carriers which will remain for a life time in contact with the tissue. This will trigger a long term inflammation process and a risk of delayed healing.
YUKON CHOICE PC has a small layer of biodegradable drug carrier. It means that our PLA is fully biodegraded from the stent after 6-9 months. So no long term inflammation process is triggered which avoids delayed healing.